Objective: To investigate the feasibility and short-term efficacy of new purse-string technique in totally laparoscopic radical resection for lower rectal cancer. Methods: The data of 6 patients with low rectal cancer undergoing totally laparoscopic radical resection with new purse-string technique were analyzed. In these patients, after totally laparoscopic total mesorectal excision, the anvil of the circular-stapling device secured with a suture needle was inserted into the lumen of the sigmoid colon through an incision on the sigmoid colon wall close to the proximal transection margin, and then the accompanying needle was advanced through colonic wall and pulled out so that the center rod of the anvil penetrated the colonic wall, following which the colon was transected by a linear cutter stapler near the site to secure the anvil. Next, the distal tumor-bearing rectosigmoid colon was everted and pulled transanally outside the body, staple-closure and transection of the distal rectum was done under direct vision, and then anastomosis was performed. Results: The operative procedures were successfully completed in all the 6 patients, and there was no conversion to laparotomy. The operative time was (165±21) min and intraoperative blood loss was (55±12) mL. No anastomotic leakage occurred, and no local recurrence or distant metastasis was found in any of the patients during follow-up. Conclusion: Using new purse-string technique in totally laparoscopic lower rectal cancer resection has high safety and significant short-term results, but the long-term results require further evaluation.