Objective: To analyze and compare the influences of carotid endarterectomy (CEA) and carotid artery stenting (CAS) on cerebral perfusion in patients with carotid stenosis during perioperative period by means of whole brain computed tomography perfusion (WBCTP). Methods: According to the criterion of the North American Symptomatic Carotid Endarterectomy Trial (NASCET), 32 patients with carotid stenosis that was confirmed by whole brain angiography were selected. Of the patients, 11 cases underwent CEA, and 21 cases underwent CAS. All patients underwent WBCTP examination before and one week after operation, and the cerebral perfusion data were recorded. The changes and degrees of the changes in the perfusion parameters that included regional cerebral blood flow (rCBF), regional cerebral blood volume (rCBV), and regional mean transit time (rMTT) of the two groups of patients were analyzed and compared. Results: Compared with preoperative data, rCBF, rCBV and rMTT were all significantly improved in either group (all P<0.05), but the degrees of the changes in all parameters showed no significant difference between the two groups (all P>0.05). Conclusion: Both CEA and CAS procedures can improve the cerebral perfusion in patients with carotid artery stenosis, and they also exhibit similar efficacy.