Neuroendocrine neoplasms (NENs) are a group of heterogeneous tumors derived from peptidergic neurons and neuroendocrine cells, with neuroendocrine markers, and can produce peptide hormones. The gastrointestinal tract is one of the predilection sites of NENs. The incidence of the disease is on the rise in recent years. The common treatments of gastrointestinal neuroendocrine neoplasms (GI-NENs) include surgery, endoscopic therapy, chemical therapy, biological treatment, radionuclide therapy, and others. Unified understanding on the therapy of NENs has not as yet been reported by domestic and foreign researchers.