Objective: To compare the difference in impact on quality of life in patients with liver hemangioma after enucleation and transcatheter arterial embolization (TAE). Methods: Through a questionnaire method, the gastrointestinal quality of life index (GLQI) was measured in 46patients with hepatic hemangioma before and 1 month, and 6, 12, and 15 months after operation. Of the 46 patients, 23 cases underwent enucleation (enucleation group) and 23 cases received TAE (TAE group). The changes in quality of life of the two groups of patients were compared. Results: There was no statistical difference in total GLQI between the two groups (P>0.05), but the overall changing trend of the total GLQI after operation was significantly different between the two groups, which showed a continuous increase from the first to the last month after operation in enucleation group, while an increasing trend during the first to sixth month but a evident decreasing trend for later in TAE group (F=5.331, P<0.05). Comparison between the two groups showed that the total GLQI was lower in enucleation group than that in TAE group at postoperative one month [(99.5±11.2) vs. (109.0±9.2), P<0.05], had no significant difference between the two groups at postoperative 6 months [(112.2±8.8) vs. (114.4±10.8), P>0.05], and was higher in enucleation group than that in TAE group at postoperative 12 or 15 months [(128.5±8.3) vs. (108.7±10.4), (129.2±8.5) vs. (108.2±9.5), P<0.05]. Intra-group comparison showed that in enucleation group, the total GLQI at postoperative 12 and 15 months was significantly increased compared with its preoperative one [(128.5±8.3), (129.2±8.5) vs. (111.7±9.3), P<0.05], and in TAE group, it was significantly increased at postoperative 6 months compared with its preoperative value [(114.4±10.8) vs. (108.3±9.8), P<0.05], but declined to its preoperative level at postoperative 12 and 15 months (both P>0.05). Conclusion: Enucleation is better than TAE for long-term postoperative recovery and improvement of quality of life in liver hemangioma patients.