As a member of the transient receptor potential (TRP) channels family, TRPV4 is a non-selective cation channel. It can be activated by heat, mechanical forces, phorbol ester derivatives and other physicochemical stimuli, and then participate in the maintenance of normal cell function. In recent years, many studies have focused on the role of TRPV4 in cell proliferation, differentiation, apoptosis and migration. The abnormal expression of TRPV4 is closely related to the occurrence and development of tumors. In this paper, the authors present the latest progress concerning TRPV4 channel in cancer.