Objective: To determine the application value of using double U-suture invaginated pancreaticojejunostomy (PJ) with binding purse-string sutures in the treatment of pancreatic injury. Methods: The clinical data of 9 patients with grade IV and V pancreatic injury admitted from January 2011 to January 2015 were retrospectively analyzed. Results: Of the 7 patients with grade IV injury, 5 cases were cured by closure of the stump of the head of the pancreas (U type lock-stitch and continuous sutures), and double U-suture invaginated Roux-en-Y pancreaticojejunal internal drainage and binding purse-string sutures, and 2 cases with duodenal rupture were cured by pancreaticoduodenectomy (PD) and double U-suture invaginated PJ with binding purse-string sutures. Two patients with grade V pancreatic injury were both cured by PD and double U-suture invaginated PJ with binding purse-string sutures. No severe complications such as postoperative pancreatic fistula or anastomotic bleeding occurred in any of the 9 patients. All the patients were fellowed- up, and there were no diabetes, diarrhea or other complications, and no deaths. Conclusion: Double U-suture invaginated PJ with binding purse-string sutures is feasible in surgery for pancreatic injury, and it could effectively prevent the occurrence of postoperative pancreatic fistula.