Objective: To assess the safety and efficacy of performing laparoscopic-assisted radical gastrectomy in patients with a history of prior abdominal surgery. Methods: The literature of studies comparing laparoscopy-assisted gastrectomy for patients with and without previous abdominal surgery was searched in several databases since their inception. After literature screening based on the inclusion criteria and exclusion criteria, data extraction and quality assessment, Meta-analysis was performed by Revman 5.3 software. Results: Five articles with 6 studies were finally included, involving a total of 982 patients, of whom 286 cases had a history of abdominal surgery and 696 cases did not. Results of this Meta-analysis indicated that in patients with previous history of abdominal surgery compared with those without history of abdominal surgery, the operative time was prolonged (WMD=15.51, 95% CI=12.74–18.28, P<0.05), but all other variables that included intraoperative blood loss (WMD=–0.36, 95% CI=–9.65–8.92), status of intraoperative lymph node dissection (WMD=1.78, 95% CI=–2.36–5.92), length of hospitalization (WMD=0.65, 95% CI=–0.33–1.62), and incidence of postoperative complications (OR=1.63, 95% CI=0.97–2.75) had no statistical difference (all P>0.05). Conclusion: History of abdominal surgery exerts no significant influence on performing laparoscopic-assisted gastrectomy, so this procedure is safe and feasible.