Objective: To investigate the clinical efficacy of endovascular treatment for acute iliofemoral vein thrombosis. Methods: The clinical data of 64 patients with acute iliofemoral venous thrombosis undergoing integrated endovascular therapy from January 2013 to January 2015 were retrospectively analyzed. Results: Fresh thrombus was all effectively dissolved in all patients after the treatment of catheter-directed thrombolysis with inferior vena cava filter insertion, without serious thrombolysis-related complications; 13 patients (13/64) underwent simultaneous balloon dilation due to severe iliac vein stenosis and no evident improvement of the lower limb swelling, of whom 5 cases (5/64) with a poor collateral circulation and iliac vein stenosis greater than 50% as shown by subsequent venography were subjected to second-stage stent implantation. After the integrated endovascular therapy, the postoperative circumference difference between two legs at 15 cm above the knee joint was significantly reduced compared with the preoperative value (3.87 cm vs. 7.56 cm, P<0.05). During the period of follow-up, no lower limb swelling and iliofemoral stenosis recurrence as well as intra-stent thrombosis were noted, and no lower limb pigmentation , ulcer formation, pulmonary embolism or death occurred. Conclusion: Integrated endovascular therapy of the iliac femoral vein is safe and effective for acute iliofemoral venous thrombosis. It can achieve good effect on the removal of thrombus and recanalization.