Objective: To evaluate the efficacy of interventional therapy for Budd-Chiari syndrome (BCS) caused by hepatic venous outflow obstruction. Methods: The clinical data of 14 patients with BCS due to hepatic venous outflow obstruction treated in Department of Vascular Surgery, Hainan Provincial People’s Hospital during January 2010 to January 2016 were retrospectively analyzed. Results: All the 14 patients were treated by percutaneous transhepatic angiography combined with superior/inferior vena cava two-way angiography and balloon dilatation, and recanalization was successful in all of them. All patients underwent repeat dilatation with increasing balloon diameter and of them, 9 cases had two and 5 cases had 3 dilatations during half a year. The average hepatic venous pressure of the patients was decreased obviously after the operations (preoperative value: 54 cmH2O; postoperative value: 25 cmH2O), no stent was inserted in any of the patients and the symptoms in all of them were significantly relieved. Followed-up was conducted for 12 to 48 months, no death occurred and no recurrence or severe postoperative complications were found. Conclusion: For BCS secondary to hepatic venous outflow obstruction, percutaneous transhepatic angiography combined with superior/inferior vena cava two-way angiography and balloon dilatation is a safe and effective treatment method, with low incidence of complications and satisfactory results.