Background and Aims The results of clinical practice confirmed that the effect of neoadjuvant intraperitoneal and systemic chemotherapy (NIPS) for peritoneal carcinomatosis in patients with gastric cancer is significantly superior to that of traditional lone systemic chemotherapy. In order to carry out the intraperitoneal chemotherapy safely and effectively, the intraperitoneal chemotherapy access port must be properly operated and managed. This study was conducted to explore the complications and preventive measures of intraperitoneal chemotherapy port placement in gastric cancer patients with peritoneal carcinomatosis.Methods The clinical data of gastric cancer patients undergoing an intraperitoneal chemotherapy port placement for NIPS from January 2018 to June 2020 were reviewed, and the complications as well as their causes and treatment measures after intraperitoneal chemotherapy port placement were summarized.Results A total of 1 634 patients underwent laparoscopic exploration combined with cytological examination of abdominal cavity exfoliation, by which, 137 cases (8.38%) were found having peritoneal metastases (P₁CY₁) and 189 cases (11.57%) were found to be positive for abdominal exfoliation cytology (P₀CY₁). All the 326 patients with peritoneal carcinomatosis underwent an intraperitoneal chemotherapy port placement during the operation, and the median time for intraperitoneal chemotherapy after the operation was 11.6 (0.9-26.3) months. In the whole group of patients, complications associated with intraperitoneal chemotherapy port occurred in 57 cases (17.48%), among which, infection (5.21%) and bending or kinking of the catheter (2.15%) were the main complications, followed by catheter displacement (1.84%), port cavity hematoma (1.84%), incision dehiscence (1.53%), subcutaneous masses (1.23%), catheter obstruction (1.23%), catheter rupture (0.61%), fluid extravasation (0.61%), port turnover (0.61%), and port cavity tumor seeding (0.61%). The median interval between the intraperitoneal chemotherapy port placement and the occurrence of complications was 5.4 (0.3-13.4) months. Univariate analysis found that the patient's age, presence of diabetes mellitus, experience of the surgeon, and preoperative anemia or hypoproteinemia were factors for the occurrence of postoperative complications (all P<0.05). Multivariate analysis showed that the surgeons with experience less than 30 cases (OR=8.317, 95% CI=2.023-11.883, P=0.008) was an independent risk factor for postoperative complications in patients with abdominal wall chemotherapy.Conclusion The application of intraperitoneal chemotherapy port in NIPS for peritoneal carcinomatosis of gastric cancer is safe and feasible, but attention should be paid to the associated complications, and corresponding prevention and treatment strategies should be adopted for different complications. A specialized operator with adequate experience is essential for ensuring patients undergoing an intraperitoneal chemotherapy port placement to uneventfully transition through the perioperative period.