Objective: To investigate the surgical complications in laparoscopic gastric cancer surgery as well as the prevention and treatment measures. Methods: The clinical data of 197 patients undergoing laparoscopic radical gastrectomy (laparoscopic group) from January 2009 to June 2013, and 275 patients who were subjected to open radical gastrectomy (laparotomy group) during the same period were retrospectively analyzed. The incidence of complications of the two groups was compared, and the influential factors for complications of laparoscopic gastric cancer surgery were analyzed. Results: There was no statistical difference between laparoscopic group and laparotomy group in incidence of operative complications (10.66% vs. 10.55%, P>0.05). The age, preoperative concomitant diseases and extent of lymph node metastasis of the patients, operative time, and surgeon experience were associated with the operative complications of laparoscopic gastric cancer surgery (all P<0.05). Conclusion: The occurrence of surgical complications in laparoscopic gastric cancer is associated with multiple factors. So it is necessary to pay attention to these factors and then according to the individual’s condition to design prevention and intervention strategies.