Radical gastrectomy with D2 lymph node dissection is a widely performed procedure for resectable advanced stomach cancer, however, its effect is still not satisfactory. With a deeper understanding in the metastasis process of cancer and the embryologic and anatomic aspects of the stomach, en bloc mesogastric excision (EME) proposed in recent years may be of great significance in improving the postoperative prognosis of stomach cancer. In this paper, the authors address the current research and application status of EME.