Objective: To investigate the applicable value of self-designed internal biliary drainage tube in laparoscopic common bile duct exploration (LCBDE) with primary closure. Methods: Sixty-three patients with common bile duct stones admitted during January 2013 to June 2014 were selected. Of the patients, 25 cases underwent LCBDE with primary closure and internal drainage using self-designed biliary internal drainage tube (self-designed internal drainage tube group), and 38 cases underwent LCBDE plus conventional T-tube drainage (conventional T-tube drainage group). The relevant clinical variables between the two groups were compared. Results: In self-designed internal drainage tube group compared with conventional T-tube drainage group, the operative time and intraoperative blood loss showed no significant difference (both P>0.05); the time to postoperative ambulation, length of postoperative stay and hospitalization expenses were all significantly decreased (all P<0.05), but the time for recovery of bowel function had no significant difference (P>0.05). Time for the internal drainage tube to be discharged during defecation after operation was (11.2±2.6) d, and in one case (4.0%) the tube failed to be discharged during defecation, and it was then removed by endoscopy. Conclusion: In dealing with common bile duct stones, LCBDE with primary closure and internal drainage using self-designed biliary internal drainage tube has advantages over the traditional procedure.