Objective: To review the experience of 10 years in diagnosis and treatment of Mirizzi syndrome (MS), so as to provide information for clinical practice. Methods: Twenty-seven MS patients admitted during 2004 to 2013 were reviewed. Of the patents, 3 cases received conservative treatment and 24 cases underwent surgical treatment, and the preoperative data, surgical procedures, postoperative recovery and follow-up result of the surgical patients were chiefly reviewed and analyzed. Results: In the 24 patients undergoing surgery, the preoperative diagnotic rate was 54.2% (13/24), the preoperative detection rate for MS by MRCP was higher than that by color Doppler ultrasound and abdominal CT scan, and 23 cases were diagnosed as chronic cholecystitis by postoperative pathology. In the 10 patients undergoing laparoscopic surgery, except for one case who was converted to open surgery due to severe intra-abdominal adhesions and had repeated abdominal pain after surgery, no intra- or postoperative complications occurred and long-term follow-up results were satisfactory in the remaining cases; in the 14 patients undergoing open surgery, small bile leakage occurred in 2 cases after surgery, and during follow-up, long-standing abdominal pain was noted in one case, one case had recurrence of jaundice and abdominal pain, T-tube removal was delayed in one case, and one case developed incisional hernia and intestinal obstruction. Conclusion: Preoperative diagnostic rate of MS is low, so the improvement of preoperative examination may help increase its preoperative diagnotic rate, thereby allowing a proper selection of operative procedure and reducing operative complications. Laparoscopic approach has certain superiority in treatment of MS.