Objective: To investigate the clinical features, diagnosis and treatment as well as outcomes of infected pancreatic necrosis (IPN) and IPN complicated with intestinal fistula. Methods: The clinical data of 33 IPN patients, including 10 cases complicated with intestinal fistula, admitted from January 2010 to December 2014 were retrospectively analyzed. Results: All patients underwent standardized treatment in accordance with acute pancreatitis diagnosis and treatment guideline, and patients with intestinal fistula had additional fistula repair or fistula resection and anastomosis, and peritoneal drainage according to the specific conditions. The mortality of the entire group of 33 patients was 39.4% (13/33), and the severity score (2012) was closely associated with the mortality (P<0.05). The mortality of those complicated with intestinal fistula was 40.0% (4/10), and intestinal fistula exerted no impact on the overall mortality (P>0.05), but significantly prolonged the hospital stay of the patients (P<0.05). The mortality in patients with intestinal fistula located in uncommon sites (75%, 3/4) was higher than that in patients with intestinal fistula located in common sites (16.7%, 1/6) (P<0.05). Conclusion: IPN has a relatively high mortality, and although intestinal fistula does not obviously increase mortality of IPN patients, it significantly influences the recovery of the patients, and intestinal fistula in an uncommon site may increase the mortality of the patients.