Objective: To investigate the vascular hemodynamic changes during the formation of obstructive membrane of the inferior vena cava (IVC) in Budd-Chiari syndrome (BCS) using computer simulation methods. Methods: The vascular model of BCS caused by membranous obstruction of the IVC was established based on MRA slice images, and then numerical simulation of hemodynamic parameter changes was demonstrated by using Ansys Fluent software. Results: The vascular model of BCS with membranous obstruction of the IVC was established successfully. The results of numerical simulation experiments demonstrated that during the formation of the obstructive membrane, there was a low flow speed region between the membrane and the region of confluence of the IVC and the three main hepatic veins, which increasingly enlarged with the extension of the membrane; with the development of the membrane, the low shear stress field located close to the IVC and the right hepatic vein was continuously amplified, and moreover, the shear stress gradually increased. Conclusion: The formation and development of the obstructive membrane of the IVC is a process of slow change, which may be closely related to alterations in shear stress of the wall of IVC.