Objective: To investigate the feasibility and safety of associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) in treatment of massive hepatocellular carcinoma with cirrhosis. Methods: The clinical data of two patients with massive right lobe primary hepatocellular carcinoma and concomitant cirrhosis undergoing ALPPS in Affiliated Zhongda Hospital of Southeast University in August 2014 and January 2015 respectively were retrospectively analyzed. The treatment efficacy was assessed by using perioperative variables and follow-up data. Results: Both patients underwent first-stage surgical procedures of right portal vein ligation and in situ partitioning of the liver parenchyma. The remnant liver volume was rapidly increased in both of them after the first-stage operation, which in case 1 increased to 704.8 mL (accounted for 60.3% of the standard liver volume) at postoperative day (POD) 6, and in case 2 increased to 771.3 mL (accounted for 63.6% of the standard liver volume) at POD 11. Both patients then underwent second-stage extended right hemihepatectomy. The operative time for the first-stage procedure was 240 min and 210 min respectively, with intraoperative blood loss of 600 mL in each case; the operative time for the second-stage procedures was 300 min and 325 min, with intraoperative blood losses of 1 000 mL and 800 mL, respectively. No perioperative death or serious postoperative complications occurred in either patient, and both patients were alive and no new intra- or extra-hepatic recurrence was observed in either of them during 6-month follow-up period. Conclusion: ALPPS is safe and feasible for massive liver cancer with cirrhosis.