Objective: To investigate the causal factors and clinical features of biloma in hepatocellular carcinoma (HCC) patients following interventional procedures. Methods: The clinical data of 500 HCC patients undergoing transcatheter arterial chemoembolisation (TACE) from January 2013 to January 2015 were reviewed. The risk factors for occurrence of postoperative biloma and its clinical features were analyzed. Results: Biloma occurred in 45 (9.0%) of the 500 patients after operation. Results of statistical analysis identified that presence of bile duct dilatation, history of liver resection before TACE, non-superselective intubation and use of polyvinyl alcohol (PVA) particles were risk factors for biloma (all P<0.05). Of the 45 patients with biloma, 10 cases had clinical symptoms that mainly included jaundice and fever, the average diameter of the biloma was significantly larger than that in asymptomatic patients (8.12 mm vs. 21.84 mm, P<0.05), and the biloma was reduced in 8 cases and disappeared in 2 after aspiration drainage; 35 asymptomatic patients received regular review with imaging examinations. Conclusion: For HCC patients with risk factors, preoperative assessment and preventive measures should be taken. Aspiration drainage should be performed in symptomatic biloma patients, and regular review and imaging examinations should be conducted in asymptomatic biloma patients, so as to give timely aspiration drainage for those with enlargement of biloma, which also can offer favorable results.