Objective: To investigate the endovascular treatment methods for deep venous thrombosis (DVT) of the lower extremities induced by Cockett’s syndrome (CS). Methods: The clinical data of 27 patients with DVT caused by CS treated from July 2012 to April 2016 were retrospectively analyzed. Of the patients, all cases received leg venography; 18 cases underwent placement of a temporary inferior vena cava filter, followed by iliac vein balloon dilatation and catheter-directed thrombolysis (CDT) for deep vein thrombosis, and 6 of them had stent placement; 7 cases underwent venography of the deep leg veins and simple deep vein CDT; 2 cases underwent only superficial venous thrombolysis. Results: Twenty-three patients recovered well after operation, and their deep veins were found patent by review venography, and the other 4 patients had mild to moderate leg swelling at discharge. The filters in 2 patients became permanent because of thrombus trapped inside the filter. No pulmonary embolism or critical bleeding occurred during the perioperative period. All patients were followed up for one month to 3 years (average of 18 months), of whom, 3 cases presented lower limb swelling after movement, but this did not occur in the other 24 cases, and remission rate was 88.9%; on duplex ultrasonic examination, the iliac vein was found to be occluded in 4 cases and patent in the remaining 23 cases, and the patency rate was 85.2%. Conclusion: Endovascular therapy as a safe and minimally invasive procedure can effectively deal with CS with concomitant DVT.