Objective: To investigate the clinical efficacy of stylized laparoscopic left lateral hepatic lobectomy in treatment of lesions in left lateral lobe of the liver. Methods: The clinical data of 139 patients with lesions in left lateral hepatic lobe (liver cancer, hemangioma, focal nodular hyperplasia, and intrahepatic stones) undergoing laparoscopic left lateral hepatic lobectomy from January 2009 to June 2016 in the Second Affiliated Hospital of Nanchang University were retrospectively analyzed. Of the patients, laparoscopic left lateral hepatic lobectomy in 63 cases was performed with a series of sequential and reliable procedure steps, with no requirements for meticulous dissection of the intrahepatic ducts (stylized group) and in 76 cases was performed with traditional procedures (traditional group). The main clinical variables between the two groups of patients were compared. Results: Laparoscopic left lateral hepatic lobectomy was completed in all patients in stylized group, while 5 cases in traditional group were converted to open surgery due to massive hemorrhage. In stylized group compared with traditional group, the operative time (80.4 min vs. 126.6 min), intraoperative blood loss (70.6 mL vs. 150.8 mL) and length of postoperative hospital stay (7.1 d vs. 10.4 d) were all significantly reduced (all P<0.05), while, the total hospitalization expense (35 600 yuan vs. 36 500 yuan), incidence of postoperative complications (7.9% vs. 14.5%) and postoperative 1-year recurrence rates of the liver cancer patients (11.1% vs. 14.7%) showed no statistical difference (P>0.05). Conclusion: Stylized laparoscopic left lateral hepatic lobectomy has demonstrable efficacy and the advantages of short operative time, less intraoperative blood loss and short length of hospital stay, moreover, it is simple and practicable. Thus, it is recommended to be generalized and broadly used.