Objective: To investigate the clinical efficacy of using local tumescent anesthesia technique in minimally invasive Mammotome rotation cutting for multiple solid breast lesions. Methods: Ninety-eight patients with multiple solid breast lesions undergoing minimally invasive Mammotome rotation cutting from June 2010 to July 2012 were randomly enrolled. Of the patients, 49 cases underwent surgery under traditional local infiltration anesthesia (control group), and the other 49 cases underwent surgery with local tumescent technique (observation group). The main clinical variables between the two groups of patients were compared. Results: There was no difference in age, tumor size and tumor number between the two groups of patients (all P>0.05). In observation group compared with control group, the average time for anesthesia (16.10 min vs. 31.41 min) and operative time (39.47 min vs. 62.53 min) were shortened, the anesthestic dose (0.20 mg vs. 0.31 mg) was reduced, the good anesthetic effect rate (96% vs. 82%) was increased, and incidence of anesthesia adverse reactions (0% vs. 12%) as well as incidence of operative complications (4% vs. 18%) were decreased. All the differences had statistical significance (all P<0.05). Conclusion: Using local tumescent anesthesia technique in minimally invasive Mammotome rotation cutting for multiple solid breast lesions is safe and effective, with significant clinical efficacy. It is recommended to be used in clinical practice.