Clinical practice guidelines for pancreatic cancer 2016 issued by the Japan Pancreas Society (JPS) provide 76 recommendatory opinions with their levels of evidence and grades of recommendations based on GRADE criteria targeting toward 51 specific clinical questions from 8 main subjects that include the disease concepts, diagnosis, surgical therapy for resectable pancreatic cancer, adjuvant therapy of resectable pancreatic cancer, therapy of locally advanced unresectable pancreatic cancer, therapy of metastatic pancreatic cancer, stent therapy, and palliative medicine. The guidelines relatively fully summarize and synthesize the standard clinical practice management of pancreatic cancer nowadays in Japan, and reflect the current knowledge of pancreatic cancer and status of its diagnosis and treatment, and can be used as reference for learning and practicing.