Objective: To investigate the efficacy of using preclose technique in endovascular exclusion of type B aortic dissection. Methods: One-hundred and nine patients with type B aortic dissection were designated to observation group (55 cases) and control group (54 cases). Patients in observation group received preplaced two ProGilde devices for vascular access site repair, and those in control group received the traditional repair method. The main clinical variables between the two groups of patients were compared. Results: In observation group compared with control group, the average operative time (98.2 min vs. 140.8 min), time to achieve hemostasis after sheath pulling (4.3 min vs. 9.1 min) and length of hospital stay (4.4 d vs. 5.9 d) were significantly reduced, and hospitalization cost (84 000 yuanvs. 81 000 yuan) was significantly increased (all P<0.05), while the duration of immobilization of the lower limb showed no significant difference (P>0.05). The surgical success rates and blood vessel diameters at the surgical site 3 months after operation showed no significant differences between the two groups (both P>0.05). One case in observation group and 3 cases in control group underwent repeat intervention due to apparent endoleak, and the overall incidence of complications in observation group was significantly lower than that in control group (7.27% vs. 24.07%, P<0.05). Conclusion: Using preclose technique in endovascular exclusion of type B aortic dissection is safe and efficient, with reliable surgical results and few postoperative complications.