Objective: To investigate the feasibility and clinical efficacy of using controlled low central venous pressure (CLCVP) in laparoscopic hepatic lobectomy. Methods: The clinical data of 97 patients undergoing laparoscopic hepatic lobectomy in the First Af?liated Hospital of Zhengzhou University from September 2013 to July 2017 were retrospectively analyzed. Of the patients, CLCVP was applied in 53 cases (CLCVP group) and not used in 44 cases (control group). Patients in both groups were further divided into simple laparoscopic hepatic lobectomy subgroup (left lateral lobectomy or irregular marginal lobectomy) and complex laparoscopic hepatic lobectomy subgroup (left hemihepatectomy, right hemihepatectomy, or mesohepatectomy). The main clinical variables were compared between the two groups and their subgroups. Results: Operations were successfully performed in all patients and no perioperative death occurred. Either in whole or subgroup comparison, the intraoperative urine output and liver and renal function parameters showed no significant difference between patients in CLCVP group and control group (all P>0.05). In whole comparison, the hepatic resection time and length of postoperative hospital stay showed no significant difference between the two groups (both P>0.05), but the intraoperative blood loss, number of cases requiring blood transfusion and amount of blood transfusion in CLCVP group were significantly less than those in control group (all P<0.05); in subgroup comparison, all above variables showed no significant difference in patients undergoing simple laparoscopic hepatic lobectomy between the two groups (all P>0.05), but the intraoperative blood loss, number of cases requiring blood transfusion and amount of blood transfusion in patients undergoing complex laparoscopic hepatic lobectomy in CLCVP group were significantly reduced compared with their counterparts in control group (all P<0.05). The complications above Clavien-Dindo grade III occurred in 6 patients in CLCVP group and 5 patients in control group respectively (P>0.05); no symptomic pulmonary embolism occurred in any of the patients during or after surgery. Conclusion: For patients undergoing complex laparoscopic hepatic lobectomy, using CLCVP can effectively reduce the amount of intraoperative blood loss and blood transfusion, and with no increase of risk for pulmonary embolism.