Objective: To investigate the appropriate methods of diagnosis and treatment for biliary tract obstruction secondary to juxtapapillary duodenal diverticula (JPPD). Methods: The clinical data of 22 patients with JPPD caused biliary tract obstruction treated in the First Affiliated Hospital of Kunming Medical University in recent years were analyzed, along with literature review. Results: Of the 22 patients, 14 cases were definitely diagnosed by endoscopic retrograde cholangiopancreatography (ERCP), 8 cases were confirmed by magnetic resonance cholangiopancreatography (MRCP); one case underwent diverticulum resection alone, 2 cases underwent diverticulum resection and choledochostomy with T-tube drainage, 15 cases underwent Billroth II gastrectomy and choledochostomy with T-tube drainage, 3 cases underwent Roux-en-Y choledochojejunostomy, and one case underwent pancreaticoduodenectomy. Twenty patients were followed up for 1.5 to 10 years, and all recovered well. Conclusion: For JPPD caused biliary tract obstruction, MRCP is the best diagnostic method at present; simple diverticulum resection is the most ideal surgical approach, Billroth II gastrectomy and choledochostomy with T-tube drainage is a simple, safe and effective approach and is most widely used, and Roux-en-Y choledochojejunostomy can be performed for those with stenosis of the sphincter of Oddi.