Objective: To investigate the diagnosis and treatment methods as well as prognosis of pancreatic neuroendocrine tumors (pNETs). Methods: The clinical data of 8 patients with pNETs treated from January 2008 to January 2017 in the Affiliated Hospital of Inner Mongolia Medical University were retrospectively analyzed. Results: Of the 8 patients, two cases were male and 6 cases were female, and the age ranged from 36 to 72 years with an average age of 53 years; the lesions in all cases were ascertained by imaging examinations; 5 cases were non-functioning tumors with main symptoms of abdominal pain or bloating, abdominal mass, inappetence and emaciation, and 3 caseswere functioning tumors with main symptoms of hypoglycemic reaction or hyperglycemia; one case underwent tumor enucleation, two cases underwent distal pancreatectomy, 4 cases underwent pancreaticoduodenectomy and one case underwent distal pancreatectomy plus splenectomy with pancreaticojejunostomy. The 8 patients were followed up for 30 to 66 months, during which period, 7 cases were still alive, and one case died. Conclusion: Combination of laboratory tests and imaging examinations will be helpful for the diagnosis of this condition, and rational and feasible combined treatment can increase the cure rate, and improve the quality of life and prognosis of the patients.