Objective: To analyze the clinical features as well as the diagnosis and treatment methods of pancreatic neuroendocrine neoplasms (PNENs). Methods: The clinical data of 5 patients with PNENs treated from June 2013 to June 2016 were retrospectively analyzed. Results: Of the 5 patients, 2 cases were male and 3 were female and age ranged from 48 to 57 years. All of the cases underwent ultrasound and CT examination, and one case had PET-CT examination. The clinical manifestations were varied with no specificity and the results of laboratory tests showed no significant findings. Four cases underwent surgical treatment, and one case underwent puncture biopsy only. The pathological results (based on the 2010 WHO classification) showed stage G1 in 2 cases, stage G2 in 1 case, and stage G3 in 2 cases, respectively. All of the 5 patients were followed up; one case died at 12 months postoperatively due to liver metastasis and the remaining cases recovered well. Conclusion: Most PNENs lack characteristic clinical manifestations, so preoperative diagnosis is difficult and it mainly depends on postoperative pathology. Surgery-based multimodality therapy is the main treatment method for PNENs, and offers better prognosis.