Colorectal cancer is one of the most common malignant tumors, with morbidity and mortality ranking on the top five among all cancers. In recent years, an increasing number of reports indicate that the incidence of colorectal cancer is on the rise in younger population, with more advanced stage and worse prognosis. However, the understandings on the definition, risk factors, clinical features, treatment methods and prognosis of the young-onset colorectal cancer are still limited. Here, the authors address the above aspects with review of the latest research at home and abroad to provide a reference for clinical practice.