Objective: To assess the relations of alcohol dehydrogenase 1C (ADH1C) gene polymorphisms with the susceptibility to alcoholic liver cirrhosis (ALC) through Meta-analysis. Methods: The relevant case-control studies were retrieved by searching several national and international databases from their inception to October 2017. Statistical analyses were performed by using Stata 12.0 software. Results: A total of 14 case-control studies were included, involving 1 457 patients in case group and 2 715 subjects in control group. Results of the entire group showed that the risk of ALC was significantly increased in allele model (OR=1.17, 95% CI=1.02–1.34, P=0.013), heterozygous model (OR=1.39, 95% CI=1.16–1.66, P=0.035), homozygous model (OR=1.27, 95%CI=1.02–1.58, P=0.036) and dominant model (OR=1.37, 95% CI=1.16–1.63, P=0.027), but had no significant change in recessive model (OR=1.19, 95% CI=0.98–1.44, P=0.052). Results of subgroup analysis showed that the risk of ALC among Asian populations was increased in allele model (OR=1.43, 95% CI=1.07–1.90, P=0.037), heterozygous model (OR=1.53, 95%CI=1.14–2.04, P=0.034), homozygous model (OR=1.52, 95% CI=1.05–2.18, P= 0.036), dominant model (OR=1.52, 95% CI=1.14–2.03, P=0.039) and recessive model (OR=1.51, 95% CI=1.08–2.11, P=0.016), while an increased risk of ALC was only found in heterozygous model (OR=1.31, 95% CI=1.04–1.64, P=0.038) and dominant model (OR=1.30, 95% CI=1.05–1.60, P=0.022) among Caucasian populations. Conclusion: ADH1C gene polymorphism is closely related to ALC susceptibility, and those with heterozygous mutation, homozygous mutation and mutant allele genotype may have increased risk of ALC.