Objective: To investigate the feasibility and safety of laparoscopic transabdominal preperitoneal (TAPP) repair in treatment of irreducible inguinal hernia. Methods: The surgical and follow-up data of 118 patients with irreducible inguinal hernia undergoing laparoscopic TAPP from January 2011 to December 2016 in the Department of Hernia and Abdominal Wall Surgery of Beijing Chaoyang Hospital were retrospectively analyzed. Results: Of the 118 patients, 90 cases (76.3%) underwent standard TAPP procedure, and 28 cases (23.7%) underwent small incision-assisted TAPP. In the entire group of patients, the operative time was 50(40–65)min, intraoperative blood loss was 5(3–10) mL, length of postoperative hospital stay was 2(1–3) d, and hospitalization cost was 9 696(9 012–11 456) yuan. The intraoperative complications occurred in 4 patients (3.4%), including vas deferens injury in one case (0.8%), spermatic vessel injury in 2 cases (1.7%) and inferior epigastric artery injury in one case (0.8%). Perioperative complications occurred in 31 cases (26.3%), including dysuria in 8 cases (6.8%), scrotum hematoma in one case (0.8%), wound pain in 21 (17.8%) cases and cognitive disorder in one case (0.8%). Twelve months of follow-up was completed in all patients, and no recurrence or infections occurred; complications occurred in 48 patients (40.7%) during period of follow-up, including seroma in 33 (28.0%) cases, foreign body sensation in 3 cases (2.5%) and chronic pain in one case (0.8%). The incidence of perioperative wound pain in patients undergoing small incision-assisted TAPP was higher than that in patients undergoing standard TAPP (46.4% vs. 8.9%, P<0.05), but no statistical differences were observed in other variables between the two procedures (all P>0.05). Conclusion: Laparoscopic TAPP is safe and feasible for the treatment of irreducible inguinal hernia under the premise of a clear diagnosis. However, the procedure should be decided in accordance with the specific conditions during operation.