Objective: To investigate the safety and feasibility of laparoscopic radical total gastectomy via complete left approach. Methods: The clinical data of 36 patients with advanced gastric cancer undergoing laparoscopic radical total gastectomy via complete left approach from January 2016 to July 2017 were retrospectively analyzed. Results: Of the 36 patients, 20 cases were males and 16 cases were females, with an average age of (61.7±13.3) years; 19 cases had cancer of proximal stomach and 17 cases had cancer of middle third of stomach. Operation was successfully performed in all of the 36 patients who underwent operation; none of the patients required open conversion or combined excision of the spleen and other organs and there was no occurrence of intraoperative complications or serious postoperative complications. The average operative time was (228.6±45.9) min, and the average intraoperative blood loss was (82.7±25.5) mL. Postoperative pathological results showed that the average number of lymph nodes harvested was 35.5±6.2, with an average positive number of 3.9±2.1; the tumor stages included IIA in 1 case (8.3%), IIB in 2 cases (16.7%), IIIA in 4 cases (33.3%), IIIB in 3 cases (25.0%), and IIIC in 2 cases (16.7%). After operation, wound infection occurred in 2 patients (5.6%), inflammatory bowel obstruction occurred in 2 patients (5.6%), and pulmonary infection occurred in 1 case (2.8%), which were all cured with conservative treatment. Conclusion: Laparoscopic radical total gastectomy via complete left approach is safe and feasible.