Objective: To investigate the potential correlation between absolute count of peripheral blood eosinophils (EOS) and platelet (PLT) count, coagulation parameters, and C-reactive protein (CRP) in patients with venous thromboembolism (VTE).
Methods: The clinical data and results of hematological tests at the first time after admission of 908 patients with deep venous thrombosis (DVT) or pulmonary thromboembolism (PE) admitted from April 2014 to June 2017 were collected retrospectively. The differences of absolute peripheral blood EOS count along with PLT count, prothrombin time (PT), international normalized ratio (INR), activated partial thromboplastin time (APTT), thrombin time (TT), fibrinogen (FIB), D-dimer (D-D), antithrombin III (AT-III) activity, and CRP among patients with different characteristics were compared, and the correlations between peripheral blood EOS count and all other above variables were analyzed.
Results: The absolute peripheral blood EOS counts were significantly different between patients with different sex, different DVT classifications, different stages, which was in male patients significantly higher than that in female patients, in patients with mixed type significantly higher than that in patients with peripheral type, and in patient in subacute and chronic stage significantly higher than in patient in acute stage (all P<0.05); all other studied parameters also showed significant differences between or among groups stratified by some of the predefined characteristics (all P<0.05). The absolute peripheral blood EOS count was significantly correlated with PLT count, PT, INR, APTT, D-D, and CRP, and the degrees of correlation changed with the age of the patients (all P<0.05).
Conclusion: EOS can induce thrombosis by activating the coagulation system through multiple pathways and meanwhile affecting the anticoagulant system. There are differences in peripheral blood EOS levels in VTE patients of different types, and peripheral blood EOS is potentially correlated with PLT count, coagulation parameters and CRP. The results suggest that peripheral blood EOS has certain clinical significance in the judgment of disease state and estimation of prognosis for VTE.