Objective: To investigate the surgical methods for the treatment of femoral artery infected false aneurysm and evaluate the therapeutic effect and application value of using vacuum-assisted closure (VAC) device in infected wound management. 
Methods: The clinical data of 16 patients with femoral artery infected false aneurysms and underwent surgical treatment from July 2015 to April 2018 were retrospectively analyzed. 
Results: Of the16 patients, 5 cases underwent direct suture of the vascular breach, 6 cases underwent wound repair with autogenous vein, 3 cases underwent autogenous vein replacement, and the other 2 cases received aneurysm resection and local exclusion. All patients underwent drainage of the infected wounds with VAC device. Twelve patients healed after second stage suture, and 4 cases received skin flap transplantation, with an average wound healing time of 34.2 d. Follow-up for 6 months was obtained in 13 patients, and except one patient who had a wound rupture and received debridement, no wound reinfection or rupture occurred in any of the remaining 12 patients, and no relapse of arterial false aneurysm occurred in any of the patients followed up. 
Conclusion: For femoral artery infected false aneurysms, surgical treatment with debridement should be performed as early as possible. VAC device is safe and effective in management of the infected wounds.