The American Society of Hematology has issued its 2018 Guidelines for Management of Venous Thromboembolism: Treatment of Pediatric Venous Thromboembolism in 2018. The guidelines provide 30 recommendatory proposals for the treatment of venous thromboembolism in children. Based on the existing evidence-based medical data and combined with the actual problems in the treatment of pediatric thrombotic diseases, the authors emphatically interpret the recommendatory proposals for the treatment of pediatric venous thromboembolism provided by the guidelines, hoping that the medical personnel in related fields can understand and follow the guidelines.