In recent years, with the extensive use of endovascular stenting in treatment of femoropopliteal artery stenosis and occlusion disease, the in-stent restenosis (ISR) is increasingly becoming a growing problem. Although the use of drug-coated balloon (DCB) reduces the prevalence of ISR, the treatment of ISR remains a clinical challenge. Despite that, the plain old balloon angioplasty (POBA), cutting balloon, frozen balloon, and re-stent implantation have been applied in the treatment of ISR, but the results are not satisfactory. Both debulking technique and DCB have certain limitations. However, their combination can exert their respective advantages, which may be an effective way to treat ISR of the femoropopliteal artery in the future.