Objective: To investigate the safety and efficacy of using the self-designed C/S-J type self-releasing biliary stent for biliary drainage after endoscopic retrograde cholangiopancreatography (ERCP). 
Methods: A total of 184 patients with common bile duct stones admitted from October 2015 to October 2018 were allotted to three groups, and underwent ERCP and endoscopic sphincterotomy (EST) plus internal drainage with C/S-J type self-releasing biliary stent (C/S-J group, 104 cases), ERCP and EST plus endoscopic nasobiliary drainage ENBD (ENBD group, 40 cases), and ERCP and EST plus endoscopic retrograde biliary drainage (ERBD) (ERBD group, 40 cases), respectively. The incidence rates of post-ERCP acute pancreatitis (PEP) and acute cholangitis among groups were compared, and the evacuation time of the self-releasing biliary stent in C/S-J group was observed. 
Results: There were no differences in sex, age, stone size, number of stones, previous cholecystectomy and presence or absence of cholangitis among the three groups (all P>0.05). In C/S-J group, ENBD group and ERBD group, the incidence rates of PEP were 6.73% (7/104), 7.50% (3/40) and 10.00% (4/40), and the incidence rates of cholangitis were 0.96% (1/104), 0.00% (0/40) and 2.50% (1/40) respectively, and the differences among groups showed no significance (both P>0.05). In C/S-J group, the stent in two cases was shed and evacuated on the first day after ERCP, the stent in one case failed to evacuate 3 months after ERCP and then was removed with duodenoscope, and the stent in the remaining cases evacuated through the digestive tract within 9–14 d with an average of 10.2 d after ERCP, and no complications such as obstruction, perforation and bleeding of the digestive tract occurred.
Conclusion: Using the self-designed C/S-J type self-releasing biliary stent for post-ERCP biliary drainage is safe and effective, and it also can overcome the limitations of ENBD and ERBD.