Objective: To compare the short- and long-term efficacy of laparoscopic pancreaticoduodenectomy (LPD) and open pancreaticoduodenectomy (OPD) in treatment of adenocarcinoma of the papilla of Vater. 
Methods: The clinical data of 89 patients with carcinoma of the papilla of the Vater undergoing pancreaticoduodenectomy from January 2012 to December 2017 were retrospectively analyzed. Of the patients, 50 cases underwent OPD and 39 cases underwent LPD. The main clinical variables between the two groups of patients were compared.
Results: The general data were comparable between the two groups of patients. There were no significant differences in operative time and cases requiring intraoperative blood transfusion between the two groups (both P>0.05), but the intraoperative blood loss in LPD group was significantly less than that in OPD group (P<0.05). The length of postoperative hospital stay in LPD group was significantly shorter than that in OPD group (P<0.05), but the incidence rate of each postoperative complication, re-operation rate and postoperative 30 d death rate showed no significant differences between the two groups (all P>0.05). The R0 resection rates and other postoperative pathological results showed no significant difference between the two groups (all P>0.05). There were no significant differences in 1-, 3- and 5-year overall survival rates and disease-free survival rates between the two groups (all P>0.05).
Conclusion: In treatment of adenocarcinoma of the papilla of Vater, LPD offers the same oncological radicalness as OPD, without increase of complications, and the long-term outcomes of the two procedures are also similar.