Objective: To assess the application efficacy of titanium-coated polypropylene mesh (TCPM) in immediate breast reconstruction with silicone prosthesis after surgery for breast cancer.  
Methods: The clinical data of 26 patients with breast cancer undergoing immediate breast reconstruction using TCPM combined with silicone prosthesis from 2016 to 2018 were retrospectively analyzed. Of the patients, skin sparing total mastectomy was performed in 7 cases, and nipple sparing total mastectomy was performed in 19 cases. The surgical variables, postoperative outcome, complications and long-term follow-up results were analyzed.
Results: Operations were successfully completed in all of the 26 patients. The average operative time was (78.46±5.96) min, average intraoperative blood loss was (73.85±17.68) mL, and the time to postoperative tube removal was 10–14 d. The excellent/good rate of the appearance of the reconstructed breast reached 88.46% (23/26). Dorsal hematoma occurred in 3 cases immediately after operation, which were improved after drainage. Poor incision healing occurred in one case after operation, which was improved by anti-inflammatory treatment, dressing change and re-suture. Recurrent spontaneous seroma occurred in one case on 3 and 5 months after operation, which was relieved by drainage. The prosthesis and mesh were removed in one case due to rejection. Followed-up was performed for 5 to 21 months in all patients, and no local recurrence or distant metastasis was found in any of the patients.
Conclusion: In breast reconstruction with silicone prosthesis, TCPM can provide safe and effective prosthesis coverage and simplify the operation process. It is suitable for use in patients who have favorable economic conditions.