Background and Aims: With the deepening of the understanding of key anatomical markers, surgical level and the concept of complete mesocolectomy, laparoscopic right hemicolectomy is becoming increasingly mature, and the scope of lymph node dissection and digestive tract reconstruction are gradually standardized. The selection of appropriate surgical approach is also of great significance for standardizing the scope of lymph node dissection, finding the correct anatomical plane and reducing intraoperative complications. This study was performed to evaluate the feasibility and safety of laparoscopic right radical hemicolectomy for colon cancer using combined craniolateral and caudolateral approach, so as to further improve the efficacy and success rates of this operation. 
Methods: The clinical data of 120 patients undergoing laparoscopic right radical hemicolectomy for right colon cancer in the Chenzhou First People’s Hospital from November 2014 to November 2018 were retrospectively analyzed. Of the patients, 68 cases underwent operation via combined craniolateral and caudolateral approach (observation group), and 52 cases underwent operation via the traditional medial approach (control group). The main clinical variables between the two groups of patients were compared.
Results: There were no significant differences in the baseline data between the two groups of patients (all P>0.05). In observation group versus control group, the average operative time was significantly shortened (110.9 min vs. 150.9 min, P<0.05) and the average intraoperative blood loss was significantly reduced (25.5 mL vs. 50.8 mL, P<0.05), but no significant differences were  noted in the total number of lymph node dissection, quality of surgical specimens, time to the first postoperative gas passage, length of postoperative hospital stay and incidence of complications (all P>0.05). Further subgroup analysis showed that either in patients with obesity or patients with tumor of hepatic flexure of the colon, observation group was superiority to control group not only in operative time and intraoperative blood loss, but also in the time to first postoperative gas passage (all P<0.05).
Conclusion: Laparoscopic radical resection of right colon cancer through combined craniolateral and caudolateral approach is safe and feasible. With the widespread use of laparoscopic equipment and continuous improvement of instruments, the popularization of laparoscopic technology and the accumulation of surgical experience, it can be further promoted to be used in clinical practice.