Background and Aims: In recent years, the problem of colorectal cancer liver metastases (CRLM) has raised great concerned in the academic community, and a growing body of relevant research literature has emerged. This study was conducted to investigate the distribution patterns of literature and research hotspots on CRLM worldwide over the past nearly 20 years, so as to provide insights into the future research directions in this field. 
Methods: All relevant documents in the field of CRLM from 2000 to 2019 were searched from the Web of Science core collection database. The search fields that included the number annually published articles, country, journal and keywords were extracted by using bibliometric tool Bibexcel software, chart drawing and knowledge mapping were conducted by Excel and Pajek, respectively, the co-occurrence and cluster analyses of individual authors, institutions, national cooperative networks and high-frequency keywords were performed by VOSviewer software.
Results: A total of 7 965 articles related to CRLM were retrieved, and each year number of published papers after 2007 exceeded 400, which were mainly from the United States, Japan and China, containing 1 728, 1 108 and 1 078, respectively. From the perspective of fund distribution, the majority of high-yielding articles were from studies financed by funds of national level. Journals mainly concentrated on high-quality oncology journals such as JOURNAL OF CLINICAL ONCOLOGY and ANNALS OF ONCOLOGY. Twelve authors from the United States and 5 authors from France had an H index of 20 or above. In cluster analysis, 53 high-frequency keywords were clustered into 5 categories, which were successively surgery and chemotherapy, prognostic factors, auxiliary diagnosis, chemotherapy drugs and metastatic cancer. 
Conclusion: Over the past nearly 20 years, international CRLM research activities and cooperation increased continuously, but there are still large disparities among countries. Overall, the bibliometrics study identified three hotspots of CRLM: surgery and prognosis, chemotherapy, and adjuvant diagnosis. Therefore, further research on these topics may be helpful for promoting the clinical transformation of the treatment strategy, and making the management of CRLM and personalized prevention and treatment more accurate and effective in the future.