Deep venous thrombosis (DVT) is a venous reflux disorder caused by abnormal coagulation of blood in the deep veins, and often occurs in the lower extremities, characterized by a high incidence rate, high disability rate and high recurrence rate as well as insidious clinical manifestations. The disease itself and complications can significantly affect the patients’ quality of life, increase the economic burden, and also increase the social medical risk and consumption. At present, the main treatment methods include thrombolysis, anticoagulation and surgical thrombectomy, which are designated to control the disease, delay its progress and promote the recanalization of deep vein lumen. The pathogenesis of DVT is complex, and there are still many unsolved problems regarding its pathological and treatment mechanism, especially the mechanism of drug therapy needs to be solved by establishing a targeted animal model of DVT. There are many animals and methods for DVT modeling, each of which has its own advantages and disadvantages. Thus, a comprehensive comparison should be made, so as to select the most appropriate modeling method for different research purposes.