Anatomic laparoscopic hepatectomy (ALH) is one of the most difficult operations in general surgery. Being restricted by the limited operation space of laparoscopic surgery, the liver, as the largest solid organ in the human body, is difficult to manipulate and expose. In addition, uncontrollable bleeding is likely to occur during the process of liver parenchyma dissection because of the abundant blood supply of the liver and the complex structure of the intrahepatic vessels, which may lead to a forced conversion to open surgery, and therefore cause a long learning curve to achieve the skill for ALH. Although after nearly 30 years of development as well as this operation has been carried out in most large medical institutions in our country, there are few systematic explanations for the selection of individualized surgical approach, which is the premise and basis for successful implementation of ALH. Here, the authors discuss the issues about this topic.