Acute pancreatitis (AP) is an acute chemical inflammation of the pancreas, characterized by pancreatic edema, bleeding and necrosis caused by internal digestion, and it is a relatively common digestive system disease in clinical practice. Studies have found that AP is associated with cardiovascular system injury, and the degree of injury is positively correlated with the severity of AP. At present, the symptomatic supportive treatment is the main therapeutic approach for AP, and the control of pancreatitis itself is the focus of treatment. Here, the authors address the clinical manifestations of AP-induced cardiovascular injury and the research progress of relevant mechanisms, so as to provide new ideas for timely preventing AP-induced cardiovascular injury as well as reducing the mortality rate of AP.