The clinical process of hyperlipidemic pancreatitis (HLP) is different from those triggered by other causes. Its incidence rates of multiple organ dysfunction syndrome (MODS) and recurrence after hospital discharge were higher than those of non-HLP, and the complications affecting the major organs are positively correlated with the level of serum triglyceride (TG). The key to its treatment is to rapidly reduce the TG level and block systemic inflammatory response. Hemoperfusion combined with hemofiltration can effectively remove blood TG and inflammatory factors, and has become an important approach for the treatment of HLP. Herein, the authors address the application progress of combination of hemoperfusion and hemofiltration in the treatment of HLP, so as to provide referential information for clinical use.