Hepatocellular carcinoma (HCC) is a common malignant tumor of the digestive tract. Although the morbidity and mortality rates of HCC have been decreasing over the past 30 years in our country, China is still the country most afflicted by HCC worldwide. Despite the significant improvement in overall survival rate of HCC, the prognosis of patients with advanced HCC is still unsatisfactory and its treatment situation is very severe. In latest three years, a series of drugs and treatment strategies for advanced HCC have sprung up, which greatly improved the prognosis of the patients. Here, the authors summarize the progress in the treatment of advanced HCC in several fields with notable achievements.