Abstract:Abstract:Objective To study the expressions and significance of MRP and LRP in HCC.
Methods The expressions of two genes were examined in three tissues (54 cases of HCC, 24 paracancer and 12 posthepatitis cirrhosis tissues) by SP immunohistochemical and PCR techniques.
Results MRP and LRP were expressed in three tissues, with significantly higher rates in HCC than others (P<0.05). The MRP expression positively correlated with the LRP expression in HCC (r=0.312, P<0.05; r=0.328, P<0.05), and was related to the degree of HCC differentiation (P<0.05). In the patients with positive gene expression,the AFP decresing rate was higher and the average survival after chemotherapy was longer than the negative expression group(P<0.05),but there was no relationship between LRP expressions and the average survival time.
Conclusions Multidrug resistance (MDR) of HCC is related to MRP、LRP expressions, and is initiated by intrinsic MDR. Monitoring of MRP and LRP may help to prospectively evaluate drug resistance. MRP may be relates to the prognosis of HCC patients.