Abstract:Objective To study the significance and expression relationship among STAT1,STAT2 and hMLH1,hMSH2 proteins in hepatocellur carcinoma(HCC).
Methods SABC immunohistochemistry method was used to detect the expression of STAT1,STAT2,hMLH1 and hMSH2 proteins in cancer tissues and paracancer tissue from 37 patients of HCC.
Results The positive rates and expressive levels of STAT1,STAT2,and hMLH1, hMSH2 in HCC was significantly lower than those in paracancer liver tissues(P<0.05). The level of expression of the 4 proteins in welldifferented cancer tissue was significanty higher than that in poorly differentiated cancer tissue(P<0.05). A positive correlation was found for STAT1 and hMSH2,STAT2 and hMLH1,hMSH2 (P<0.05) in paracancer liver tissues.
Conclusions The data suggest that STAT1,STAT2 and hMLH1,hMSH2 may play an important roie in the early stage of malignant transformation of hepatocytes.