Abstract:Objective To study the expressions of ER, PR, mutant p53, HER2, and MDR1 genes in breast cancer, and their correlation with clinicopathologic factors and prognosis.
Methods Expressions of ER, PR, mutant p53, HER2, and MDR1 gene proteins were examined by immunohistochemistry (IHC) in breast cancer lesions from 215 patients, and their correlation with clinicopathologic features were analyzed.All of the patients were followed up for analysis of disease free survival(DFS) and overall survival(OS) rate, and survival analysis.
Results Of the 215 breast carcinoma samples, the positive rates for ER、PR、mutant p53，HER2，MDR1 gene proteins expression were 40.9%,29.0%,40.5%,37.2% and 37.7%, respectively. Overexpression of PR and mutant p53 was positively correlated with axillary lymph node (P=0.001, 0.037, respectively), and overexpression of HER2 was positively correlated with TNM staging