Abstract:Objective To study the expression levels of p16,p53,CDK4/cyclinD1 protein in breast cancer and their relationship to prognosis. 〖WTHZ〗Methods〓〖WTBZ〗The expression of p16,p53,CDK4 and cyclinD1 in breast cancer tissues of 86 patients who did not receive preoperative chemotherapy were examined,and the relationship of their expression to clinicopathological data were analyzed.〖WTHZ〗Results〓〖WTBZ〗(1)p16,p53,CDK4:The positive expression of p16,p53 and CDK4 were significantly different in stages I and II infiltrating ductal carcinoma,but cyclin D showed no difference;their positive expression in lymph node negative and lymph node positive groups were significantly different;their positive expression for patients′age≤50 years and>50 years showed no significat difference;there was significant difference of p53 expression between ER negative and ER positive groups,but p16,CDK4 and cyclin D expression showed no difference;p53 expression was significantly different in ER negative and PR positive groups,but the levels of the other proteins were not significantly different.(2)There were significant differences between the expression of p16 and p53