Abstract:Objective To explore the effect of lysolecithin choline (LPC) on bloodbrain barrier(BBB) permeability in rats with acute pancreatitis.
Methods Acute pancreatitis rat model was produced and rats were randomly divided into:(1)Test groupAP, rats received LPC by tail vein injection; (2)control group I, AP rats were given normal saline by tail vein injection; (3)control group II, sham operation without AP, but LPC was given by tail vein injection.Horseradish peroxidase(HRP) was used as a tracer to determine BBB permeability 7~10 days later.
Results The test group showed local extravascular effusion of HRP,indicating that BBB permeability was markedly increased,while both control groups showed no apparent increase of BBB permeability,which were statistically significant(P<0.01,P<0.05).
ConclusionsLPC can increase BBB permeability of rats with acute pancreatitis,and this may be related to the development of pancreatic encephalopathy.